The OFF-X portal uses cookies. You can change your cookie preferences in your browser settings. If you agree to the use of cookies, please click OK. For more information on our use of cookies, please see our Cookie Policy.
OK
COVERAGE AS OF
SEPTEMBER 2021:
1,368,643SAFETY ALERTS
15,348TARGETS & GENES
24,863DRUGS, BIOLOGICS & DRUG COMBINATIONS
10,902ADVERSE EVENTS
COVERAGE AS OF SEPTEMBER 2021:
1,368,643
SAFETY ALERTS
15,348
TARGETS & GENES
24,863
DRUGS, BIOLOGICS & DRUG COMBINATIONS
10,902
ADVERSE EVENTS
WEEKLY REPORTS
COVID-19 DAILY ALERTS
SELECTED
DAILY ALERTS
FEATURED
CONGRESS REPORTS
Our editorial team covers more than 500 scientific conferences each year. Select a congress to discover safety insights made public for the first time:
  • SELECTED
    REPORTS
  • UPCOMING
    CONGRESSES
Sep 16-21
ESMO Congress 2021 , Virtual
IN PROGRESS
Sep 9-12
EURETINA 2021, Virtual
IN PROGRESS
Sep 8-11
18th International Myeloma Workshop (IMW) 2021, Vienna
IN PROGRESS
Sep 8-11
Society of Hematologic Oncology (SOHO) Annual Meeting 2021, Virtual
IN PROGRESS
Sep 8-12
The International Headache Congress, IHS and EHF Joint Congress 2021, Virtual
IN PROGRESS
Sep 5-8
European Respiratory Society International Congress (ERS) 2021, Virtual
Sep 2-5
15th ILCA Conference 2021, Virtual
Sep 1-3
European Stroke Organisation Conference ​(ESOC) 2021, Virtual
IN PROGRESS
Aug 29-Sep 1
20th Congress of the European Society for Organ Transplantation (ESOT) 2021, Milan & Online
Aug 28-Sep 1
34th International Epilepsy Congress 2021, Virtual
Aug 28-31
European Human Genetics Conference (ESHG) 2021, Virtual
Aug 27-30
European Society of Cardiology (ESC) Congress 2021, Digital
Aug 26-28
NHF Bleeding Disorders Conference 2021, Virtual
Aug 26-28
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO IOF-ESCEO) 2021, Virtual
Aug 23-25
Basic Cardiovascular Sciences Scientific Sessions (BCVS) 2021, Virtual
Aug 12-15
Pan-American Congress of Rheumatology (PANLAR) 2021, Virtual
Aug 7-8
14th Australasian Cystic Fibrosis Conference 2021, Virtual
Aug 5-8
American Academy of Dermatology (AAD) Summer Meeting 2021, Tampa
Jul 26-30
Alzheimer's Association International Conference (AAIC) 2021, Virtual
Jul 23-26
Annual Meeting of The American Society of Cataract And Refractive Surgery (ASCRS-ASOA) 2021, Las Vegas
Jul 18-21
11th International AIDS Society Conference on HIV Science 2021, Virtual
Jul 17-21
International Society on Thrombosis and Haemostasis (ISTH) Virtual Congress 2021, Virtual
Jul 12-15
28th Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB) 2021, Online
Jul 10-12
EAACI Hybrid Congress 2021, Hybrid
Jul 6-8
101st Annual Meeting of the British Association of Dermatologists 2021, Virtual
Jul 6-9
68th Society for Reproductive Investigation (SRI) Annual Scientific Meeting 2021, Boston
Jul 3-8
45th Congress of The Federation of the European Biochemical Societies (FEBS) 2021, Ljubljana
Jul 2-10
16th Congress of ECCO 2021, Virtual
Jun 30-Jul 3
9th World Glaucoma E-Congress 2021, Virtual
Jun 30-Jul 3
ESMO 23rd World Congress on Gastrointestinal Cancer 2021, Virtual
Jun 30-Jul 3
The International Federation of Psoriasis Association’s 6th World Psoriasis & Psoriatic Arthritis Conference 2021, Virtual
OFF-X ANALYTICS
DATA IN ACTION TO DE-RISK YOUR R&D PROGRAMS
OFF-X is built from the most comprehensive translational safety dataset (1,368,643 curated alerts as of September 2021). We are providing access to a series of analytics and visualization extensions to fully exploit the value of the OFF-X dataset and derive new knowledge. Select your option below and start exploring
OFF-X
ENABLING TRANSLATIONAL SAFETY
By enabling translational research, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post marketing. From target safety assessment to post-marketing signal evaluation, discover the breadth and depth of OFF-X use cases:
Translational Research Teams & Information Professionals
Biologists & Bioinformaticians
Medicinal Chemists
Toxicologists & Safety Pharmacologists
Clinical
Researchers
Pharmacovigilance Professionals
Business Development Executives
Data Scientists
0
Biologists & Bioinformaticians
  • Anticipate safety liabilities of targets entering the pipeline: Target Safety Assessment (TSA)
  • Benchmark target safety profiles across a given indication
  • Build adverse event-based systems toxicology models
Medicinal Chemists
  • Analyze structures to select candidates and optimize lead compounds by identifying toxicophores
  • Compare chemical and pharmacological insights associated to toxicological and safety endpoints
  • Build computational models to predict adverse effects from chemical structures
Toxicologists & Safety Pharmacologists
  • Anticipate and translate to the clinic toxicity and safety events derived from experimental assays and animal models
  • Develop hypotheses for off-target effects (secondary pharmacology profiling) and guide experimental assay planning
  • Determine if an adverse event is compound-related or target-related
  • Stay up-to-date on liabilities associated with a therapeutic target of interest
Clinical Researchers
  • Obtain actionable insights to design first-in-human trials and anticipate safety signals
  • Benchmark the safety profile of compounds as they advance in development
  • Discover mechanisms behind unexpected adverse events observed in a clinical trial
Pharmacovigilance & Patient Safety Professionals
  • Evaluate safety signals that do not appear on a drug's label
  • Compare findings from international regulatory agencies
  • Track & benchmark the evolution of safety evidence over a compound’s or target’s life cycle and compare it with that of others drugs
  • Monitor emerging class liabilities
  • Assess and compare the safety evidence available for a set of targets in a given indication
Business Development Executives
  • Perform safety evidence benchmarking
  • Provide an independent safety risk assessment of licensing opportunities
Data Scientists
  • Expand and integrate expertly curated information with your in-house data
  • Enhance artificial intelligence applications with high quality curated data
  • Improve the performance of predictive analytics
  • Build adverse event-based systems toxicology models
  • Build chemoinformatic models to predict adverse effects from chemical structures
  • Extend the value of your visualization capabilities to better support internal projects
15,348TARGETS & GENES
24,863DRUGS, BIOLOGICS & DRUG COMBINATIONS
1,368,643SAFETY ALERTS
10,902ADVERSE EVENTS
OFF-X API
EMPOWER YOUR INTERNAL SAFETY INTELLIGENCE
Connect to the most comprehensive translational safety data ecosystem through our APIs or data feed licenses. As of September 2021, OFF-X covers More than 15,348 targets, 24,863 drugs and biologics, 10,902 toxicity endpoints and adverse events. Updated daily, the portal is populated with a unique pool of more than 1,368,643 expertly curated safety alerts.

By integrating the OFF-X data with in-house information sources and modeling applications our customers are able to:
  • Enrich and expand the breadth & depth of internal resources coverage
  • Build Artificial Intelligence models with high quality curated data
  • Enhance the performance of predictive analytics
Click here to learn more about OFF-X API (api.targetsafety.info)
OFF-X
NEWS