The OFF-X portal uses cookies. You can change your cookie preferences in your browser settings. If you agree to the use of cookies, please click OK. For more information on our use of cookies, please see our Cookie Policy.
OK
COVERAGE AS OF
DECEMBER 2021:
1,443,680SAFETY ALERTS
15,340TARGETS & GENES
25,818DRUGS, BIOLOGICS & DRUG COMBINATIONS
11,025ADVERSE EVENTS
COVERAGE AS OF DECEMBER 2021:
1,443,680
SAFETY ALERTS
15,340
TARGETS & GENES
25,818
DRUGS, BIOLOGICS & DRUG COMBINATIONS
11,025
ADVERSE EVENTS
WEEKLY REPORTS
COVID-19 DAILY ALERTS
SELECTED
DAILY ALERTS
FEATURED
CONGRESS REPORTS
Our editorial team covers more than 500 scientific conferences each year. Select a congress to discover safety insights made public for the first time:
  • SELECTED
    REPORTS
  • UPCOMING
    CONGRESSES
Nov 12-15
AASLD, The Liver Meeting Digital Experience 2021, Digital
IN PROGRESS
Nov 10-14
36th Anniversary Annual Meeting SITC 2021, Washington & Virtually
IN PROGRESS
Oct 23-24
ASTRO Annual Meeting 2021, Virtual
Oct 22-27
American College of Gastroenterology (ACG) 2021, Las Vegas
IN PROGRESS
Oct 22-23
ESMO Virtual Preceptorship on Gastric Cancer 2021, Virtual
Oct 17-19
146th Annual Meeting American Neurological Association (ANA) 2021, Virtual
IN PROGRESS
Oct 17-20
77th Scientific Congress of the American Society for Reproductive Medicine (ASRM) 2021, Baltimore
IN PROGRESS
Oct 17-20
CHEST Annual Meeting 2021, Virtual
Oct 16-18
North American Congress of Clinical Toxicology (NACCT) 2021, Virtual
IN PROGRESS
Oct 14-16
EORTC CL Group 20-21 Meeting on Cutaneous Lymphoma 2021, Hybrid
Oct 14-15
Global Congress on Bladder Cancer 2021, Hybrid
Oct 13-15
47th Annual Meeting of the International Society for Pediatric and Adolescent Diabetes (ISPAD) 2021, Virtual
Oct 13-15
ECTRIMS Digital Congress 2021, Digital
Oct 13-14
ESMO Virtual Advanced Course on KRAS Targeting in NSCLC 2021, Virtual
Oct 11-15
Virtual World Congress of Psychiatric Genetics (WCPG) 2021, Virtual
Oct 8-11
10th Trends in Medical Mycology (TIMM) 2021, Aberdeen
Oct 8-12
The Anesthesiology Annual Meeting 2021, San Diego
Oct 7-9
British Society for Allergy and Clinical Immunology (BSACI) Conference 2021, Harrogate
Oct 7-9
Molecular Analysis for Precision Oncology (MAP) Virtual Congress 2021, Virtual
Oct 6-9
LUPUS CORA Meeting 2021, Virtual
Oct 5-8
Virtual PWS Family Conference 2021, Virtual
Oct 3-5
UEG Week Virtual 2021, Virtual
Oct 3-7
XXV Biennial World Congress of Neurology 2021, Virtual
Oct 2-5
34th ECNP Congress 2021, Lisbon
Sep 30-Oct 3
90th Annual Meeting of the American Thyroid Association 2021, Virtual
Sep 29-Oct 2
30th European Academy of Dermatology and Venerology (EADV) Congress 2021, Virtual
Sep 29-30
AACR Virtual Special Conference: Pancreatic Cancer 2021, Virtual
Sep 28-Oct 1
57th Annual Meeting of the European Association for the Study of Diabetes (EASD) 2021, Virtual
Sep 27-Oct 1
56th Congress of the European Societies of Toxicology (EUROTOX) 2021, Virtual
Sep 27-29
American Heart Association's Hypertension Scientific Sessions 2021, Virtual
Sep 26-29
17th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS) 2021, Virtual
Sep 26-30
AACC Annual Scientific Meeting & Clinical Lab Expo 2021, Atlanta
Sep 23-26
16th International Symposium on Myelodysplastic Syndromes 2021, Virtual
Sep 22-25
50th Annual European Society for Dermatologic Research (ESDR) Meeting 2021, Virtual
Sep 22-26
59th Annual European Society for Paediatric Endocrinology (ESPE) Meeting 2021, Online
Sep 20-24
WMS Virtual Congress 2021, Virtual
Sep 19-22
19th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology (IATDMCT) 2021, Rome
Sep 19-21
27th European Paediatric Rheumatology Congress (PReS) 2021, Virtual
Sep 17-22
MDS Virtual Congress 2021, Virtual
Sep 16-17
Digital NAFLD Summit 2021, Digital
Sep 16-21
ESMO Congress 2021 , Virtual
Sep 13-17
24th North American Meeting of the International Society for the Study of Xenobiotics (ISSX) 2021, Virtual
Sep 13-17
Annual Meeting of the American College of Clinical Pharmacology (ACCP) 2021, Virtual
Sep 10-13
American Urological Association (AUA) Annual Meeting 2021, Virtual
Sep 10-13
HFSA Virtual Annual Scientific Meeting 2021, Denver
Sep 9-12
EURETINA 2021, Virtual
Sep 9-11
European Huntington's Disease Network (EHDN) Plenary Meeting 2021, Remote
Sep 9-11
Society for Vascular Medicine (SVM) Virtual Scientific Sessions 2021, Virtual
Sep 8-11
18th International Myeloma Workshop (IMW) 2021, Vienna
Sep 8-11
Society of Hematologic Oncology (SOHO) Annual Meeting 2021, Virtual
Sep 8-12
The International Headache Congress, IHS and EHF Joint Congress 2021, Virtual
Sep 8-14
World Conference on Lung Cancer 2021, Virtual
Sep 7-11
PAINWeek Conference 2021, Las Vegas
OFF-X ANALYTICS
DATA IN ACTION TO DE-RISK YOUR R&D PROGRAMS
OFF-X is built from the most comprehensive translational safety dataset (1,443,680 curated alerts as of December 2021). We are providing access to a series of analytics and visualization extensions to fully exploit the value of the OFF-X dataset and derive new knowledge. Select your option below and start exploring
OFF-X
ENABLING TRANSLATIONAL SAFETY
By enabling translational research, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post marketing. From target safety assessment to post-marketing signal evaluation, discover the breadth and depth of OFF-X use cases:
Translational Research Teams & Information Professionals
Biologists & Bioinformaticians
Medicinal Chemists
Toxicologists & Safety Pharmacologists
Clinical
Researchers
Pharmacovigilance Professionals
Business Development Executives
Data Scientists
0
Biologists & Bioinformaticians
  • Anticipate safety liabilities of targets entering the pipeline: Target Safety Assessment (TSA)
  • Benchmark target safety profiles across a given indication
  • Build adverse event-based systems toxicology models
Medicinal Chemists
  • Analyze structures to select candidates and optimize lead compounds by identifying toxicophores
  • Compare chemical and pharmacological insights associated to toxicological and safety endpoints
  • Build computational models to predict adverse effects from chemical structures
Toxicologists & Safety Pharmacologists
  • Anticipate and translate to the clinic toxicity and safety events derived from experimental assays and animal models
  • Develop hypotheses for off-target effects (secondary pharmacology profiling) and guide experimental assay planning
  • Determine if an adverse event is compound-related or target-related
  • Stay up-to-date on liabilities associated with a therapeutic target of interest
Clinical Researchers
  • Obtain actionable insights to design first-in-human trials and anticipate safety signals
  • Benchmark the safety profile of compounds as they advance in development
  • Discover mechanisms behind unexpected adverse events observed in a clinical trial
Pharmacovigilance & Patient Safety Professionals
  • Evaluate safety signals that do not appear on a drug's label
  • Compare findings from international regulatory agencies
  • Track & benchmark the evolution of safety evidence over a compound’s or target’s life cycle and compare it with that of others drugs
  • Monitor emerging class liabilities
  • Assess and compare the safety evidence available for a set of targets in a given indication
Business Development Executives
  • Perform safety evidence benchmarking
  • Provide an independent safety risk assessment of licensing opportunities
Data Scientists
  • Expand and integrate expertly curated information with your in-house data
  • Enhance artificial intelligence applications with high quality curated data
  • Improve the performance of predictive analytics
  • Build adverse event-based systems toxicology models
  • Build chemoinformatic models to predict adverse effects from chemical structures
  • Extend the value of your visualization capabilities to better support internal projects
15,340TARGETS & GENES
25,818DRUGS, BIOLOGICS & DRUG COMBINATIONS
1,443,680SAFETY ALERTS
11,025ADVERSE EVENTS
OFF-X API
EMPOWER YOUR INTERNAL SAFETY INTELLIGENCE
Connect to the most comprehensive translational safety data ecosystem through our APIs or data feed licenses. As of December 2021, OFF-X covers More than 15,340 targets, 25,818 drugs and biologics, 11,025 toxicity endpoints and adverse events. Updated daily, the portal is populated with a unique pool of more than 1,443,680 expertly curated safety alerts.

By integrating the OFF-X data with in-house information sources and modeling applications our customers are able to:
  • Enrich and expand the breadth & depth of internal resources coverage
  • Build Artificial Intelligence models with high quality curated data
  • Enhance the performance of predictive analytics
Click here to learn more about OFF-X API (api.targetsafety.info)
OFF-X
NEWS