COVERAGE AS OF JANUARY 2021: |
1,011,647SAFETY ALERTS
|
15,227TARGETS & GENES
|
21,249DRUGS, BIOLOGICS & DRUG COMBINATIONS
|
9,840ADVERSE EVENTS
|
COVERAGE AS OF JANUARY 2021:
1,011,647
SAFETY ALERTS
SAFETY ALERTS
15,227
TARGETS & GENES
TARGETS & GENES
21,249
DRUGS, BIOLOGICS & DRUG COMBINATIONS
DRUGS, BIOLOGICS & DRUG COMBINATIONS
9,840
ADVERSE EVENTS
ADVERSE EVENTS
WEEKLY REPORTS
COVID-19 DAILY ALERTS
SELECTED
DAILY ALERTS
FEATURED
CONGRESS REPORTS
Our editorial team covers more than 500 scientific conferences each year. Select a congress to discover safety insights made public for the first time:
Jan 15-17
ASCO Gastrointestinal Cancers Symposium 2021, Virtual
IN PROGRESS
Dec 14-16
European Congress of Oncological Gynecology (ESGO) Virtual Annual Meeting 2020, Virtual
Dec 13-16
The 19th International Symposium on Pediatric Neuro-Oncology (ISPNO) 2020, Karuizawa
Dec 8-11
San Antonio Breast Cancer Symposium (SABCS) 2020, Virtual
Dec 6-9
59th Annual Meeting of the American College of Neuropsychopharmacology (ACNP) 2020, Virtual
Dec 5-8
62nd American Society of Hematology (ASH) Annual Meeting and Exposition 2020, Virtual
Dec 4-8
American Epilepsy Society (AES) Annual Meeting 2020, Virtual
Dec 3-5
Society of Urologic Oncology 21st Annual Meeting 2020, Virtual
Nov 20-22
ESMO Asia Virtual Congress 2020, Virtual
Nov 13-14
12th European Multidisciplinary Congress on Urological Cancers 2020 (EMUC20), Virtual
Nov 13-16
AASLD, The Liver Meeting Digital Experience 2020, Digital
Nov 13-15
American College of Allergy, Asthma, and Immunology (ACAAI) Annual Scientific Meeting 2020, Virtual
Nov 13-17
American Heart Association's (AHA) 2020 Scientific Sessions, Virtual
Nov 13-15
Fall Clinical Dermatology Conference® for PAs & NPs, Virtual
Nov 9-14
35th Anniversary Annual Meeting SITC 2020, Virtual
Nov 5-9
ACR Convergence 2020, Virtual
Nov 4-7
13th Clinical Trials on Alzheimer's Disease (CTAD) Conference 2020, Virtual
Nov 1-7
North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Annual Meeting 2020, Virtual
OFF-X ANALYTICS
DATA IN ACTION TO DE-RISK YOUR R&D PROGRAMS
OFF-X is built from the most comprehensive translational safety dataset (1,011,647 curated alerts as of January 2021). We are providing access to a series of analytics and visualization extensions to fully exploit the value of the OFF-X dataset and derive new knowledge. Select your option below and start exploring
OFF-X
ENABLING TRANSLATIONAL SAFETY
By enabling translational research, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post marketing. From target safety assessment to post-marketing signal evaluation, discover the breadth and depth of OFF-X use cases:
Translational Research Teams & Information Professionals
Biologists & Bioinformaticians
Medicinal Chemists
Toxicologists & Safety Pharmacologists
Clinical
Researchers
Researchers
Pharmacovigilance Professionals
Business Development Executives
Data Scientists

Biologists & Bioinformaticians
- Anticipate safety liabilities of targets entering the pipeline: Target Safety Assessment (TSA)
- Benchmark target safety profiles across a given indication
- Build adverse event-based systems toxicology models


Medicinal Chemists
- Analyze structures to select candidates and optimize lead compounds by identifying toxicophores
- Compare chemical and pharmacological insights associated to toxicological and safety endpoints
- Build computational models to predict adverse effects from chemical structures


Toxicologists & Safety Pharmacologists
- Anticipate and translate to the clinic toxicity and safety events derived from experimental assays and animal models
- Develop hypotheses for off-target effects (secondary pharmacology profiling) and guide experimental assay planning
- Determine if an adverse event is compound-related or target-related
- Stay up-to-date on liabilities associated with a therapeutic target of interest


Clinical Researchers
- Obtain actionable insights to design first-in-human trials and anticipate safety signals
- Benchmark the safety profile of compounds as they advance in development
- Discover mechanisms behind unexpected adverse events observed in a clinical trial


Pharmacovigilance & Patient Safety Professionals
- Evaluate safety signals that do not appear on a drug's label
- Compare findings from international regulatory agencies
- Track & benchmark the evolution of safety evidence over a compound’s or target’s life cycle and compare it with that of others drugs
- Monitor emerging class liabilities
- Assess and compare the safety evidence available for a set of targets in a given indication


Business Development Executives
- Perform safety evidence benchmarking
- Provide an independent safety risk assessment of licensing opportunities


Data Scientists
- Expand and integrate expertly curated information with your in-house data
- Enhance artificial intelligence applications with high quality curated data
- Improve the performance of predictive analytics
- Build adverse event-based systems toxicology models
- Build chemoinformatic models to predict adverse effects from chemical structures
- Extend the value of your visualization capabilities to better support internal projects
15,227TARGETS & GENES
|
21,249DRUGS, BIOLOGICS & DRUG COMBINATIONS
|
1,011,647SAFETY ALERTS
|
9,840ADVERSE EVENTS
|
OFF-X API
EMPOWER YOUR INTERNAL SAFETY INTELLIGENCE

Connect to the most comprehensive translational safety data ecosystem through our APIs or data feed licenses. As of January 2021, OFF-X covers More than 15,227 targets, 21,249 drugs and biologics, 9,840 toxicity endpoints and adverse events. Updated daily, the portal is populated with a unique pool of more than 1,011,647 expertly curated safety alerts.
By integrating the OFF-X data with in-house information sources and modeling applications our customers are able to:
Click here to learn more about OFF-X API (api.targetsafety.info)
By integrating the OFF-X data with in-house information sources and modeling applications our customers are able to:
- Enrich and expand the breadth & depth of internal resources coverage
- Build Artificial Intelligence models with high quality curated data
- Enhance the performance of predictive analytics
OFF-X
NEWS

BIOINFOGATE’S OFF-X REACHES ONE MILLION SAFETY ALERTS
OFF-X has become the largest translational safety and toxicity intelligence portal for drugs and targets of pharmacological interest.
January 18, 2021

NEW COLLABORATION BETWEEN BIOINFOGATE AND INTAGE HEALTHCARE TO DELIVER JAPANESE PHARMACOVIGILANCE INSIGHTS IN OFF-X
Bioinfogate will integrate JADER case reports and pharmacovigilance signals into OFF-X to complement its unique translational view of safety intelligence.
October 15, 2020

LAUNCH OF BIOINFOGATE’S OFF-X TRANSLATABILITY DASHBOARD
The Translatability Dashboard supports understanding of how toxicity events derived from experimental assays and animal models translate to the clinic
July 23, 2020

FDA AND BIOINFOGATE AGREE TO EXTEND THE MATERIAL TRANSFER AGREEMENT (MTA) TO ACCESS THE OFF-X TRANSLATIONAL SAFETY INTELLIGENCE PORTAL
The agreement aims to evaluate new approaches to enhance safety assessments of human pharmaceuticals and their associated molecular targets, supporting the FDA’s mission of protecting public health.
May 21, 2019
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