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COVERAGE AS OF
AUGUST 2021:
1,331,832SAFETY ALERTS
15,334TARGETS & GENES
24,592DRUGS, BIOLOGICS & DRUG COMBINATIONS
10,804ADVERSE EVENTS
COVERAGE AS OF AUGUST 2021:
1,331,832
SAFETY ALERTS
15,334
TARGETS & GENES
24,592
DRUGS, BIOLOGICS & DRUG COMBINATIONS
10,804
ADVERSE EVENTS
WEEKLY REPORTS
COVID-19 DAILY ALERTS
SELECTED
DAILY ALERTS
FEATURED
CONGRESS REPORTS
Our editorial team covers more than 500 scientific conferences each year. Select a congress to discover safety insights made public for the first time:
  • SELECTED
    REPORTS
  • UPCOMING
    CONGRESSES
Jul 18-21
11th International AIDS Society Conference on HIV Science 2021, Virtual
IN PROGRESS
Jun 30-Jul 3
ESMO 23rd World Congress on Gastrointestinal Cancer 2021, Virtual
Jun 29-Jul 1
Heart Failure 2021, Online
IN PROGRESS
Jun 28-29
EACPT Virtual Meeting 2021, Virtual
IN PROGRESS
Jun 25-29
81st Scientific Sessions of the American Diabetes Association 2021, Virtual
IN PROGRESS
Jun 24-Jul 1
61st Annual Meeting of the Society for Birth Defects Research and Prevention 2021, Virtual
Jun 23-26
The International Liver Congress™ 2021, Virtual
Jun 22-22
Society for Endocrinology National Clinical Cases 2021, Online
Jun 21-22
ESMO Virtual Preceptorship on Gastroenteropancreatic and Lung Neuroendocrine Neoplasms 2021, Virtual
Jun 21-26
ISSCR 2021 Virtual, Virtual
Jun 19-22
7th Congress of the European Academy of Neurology (EAN) 2021, Virtual
Jun 18-22
16th International Conference on Malignant Lymphoma 2021, Virtual
Jun 10-11
ESMO Virtual Summit Russia 2021, Virtual
Jun 10-13
SLEEP Virtual Meeting 2021, Virtual
Jun 9-12
44th European Cystic Fibrosis Conference 2021, Virtual
Jun 9-17
European Hematology Association (EHA) Virtual 2021, Virtual
Jun 5-8
58th ERA-EDTA Congress 2021, Virtual
Jun 4-8
ASCO Annual Meeting 2021, Virtual
Jun 3-6
63rd Annual Scientific Meeting American Headache Society (AHS) 2021, Virtual
Jun 2-5
6th World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition (WCPGHAN) Meeting 2021, Virtual
Jun 2-5
EULAR Congress 2021, Virtual
Jun 2-5
The 14th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD) 2021, Virtual
May 21-23
Digestive Disease Week (DDW) 2021, Virtual
May 14-19
American Thoracic Society (ATS) International Conference 2021, Virtual
May 13-15
46th Annual Regional Anesthesiology and Acute Pain Medicine Meeting 2021, Virtual
May 13-15
American Geriatrics Society Virtual Annual Scientific Meeting 2021, Virtual
May 12-13
ESMO Virtual Plenaries 2021, Virtual
May 12-14
European Network for the Cure of ALS Meeting (ENCALS) 2021, Virtual
May 11-14
24th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) 2021, Virtual
May 10-12
18th CIMT Annual Meeting 2021, Virtual
OFF-X ANALYTICS
DATA IN ACTION TO DE-RISK YOUR R&D PROGRAMS
OFF-X is built from the most comprehensive translational safety dataset (1,331,832 curated alerts as of August 2021). We are providing access to a series of analytics and visualization extensions to fully exploit the value of the OFF-X dataset and derive new knowledge. Select your option below and start exploring
OFF-X
ENABLING TRANSLATIONAL SAFETY
By enabling translational research, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post marketing. From target safety assessment to post-marketing signal evaluation, discover the breadth and depth of OFF-X use cases:
Translational Research Teams & Information Professionals
Biologists & Bioinformaticians
Medicinal Chemists
Toxicologists & Safety Pharmacologists
Clinical
Researchers
Pharmacovigilance Professionals
Business Development Executives
Data Scientists
0
Biologists & Bioinformaticians
  • Anticipate safety liabilities of targets entering the pipeline: Target Safety Assessment (TSA)
  • Benchmark target safety profiles across a given indication
  • Build adverse event-based systems toxicology models
Medicinal Chemists
  • Analyze structures to select candidates and optimize lead compounds by identifying toxicophores
  • Compare chemical and pharmacological insights associated to toxicological and safety endpoints
  • Build computational models to predict adverse effects from chemical structures
Toxicologists & Safety Pharmacologists
  • Anticipate and translate to the clinic toxicity and safety events derived from experimental assays and animal models
  • Develop hypotheses for off-target effects (secondary pharmacology profiling) and guide experimental assay planning
  • Determine if an adverse event is compound-related or target-related
  • Stay up-to-date on liabilities associated with a therapeutic target of interest
Clinical Researchers
  • Obtain actionable insights to design first-in-human trials and anticipate safety signals
  • Benchmark the safety profile of compounds as they advance in development
  • Discover mechanisms behind unexpected adverse events observed in a clinical trial
Pharmacovigilance & Patient Safety Professionals
  • Evaluate safety signals that do not appear on a drug's label
  • Compare findings from international regulatory agencies
  • Track & benchmark the evolution of safety evidence over a compound’s or target’s life cycle and compare it with that of others drugs
  • Monitor emerging class liabilities
  • Assess and compare the safety evidence available for a set of targets in a given indication
Business Development Executives
  • Perform safety evidence benchmarking
  • Provide an independent safety risk assessment of licensing opportunities
Data Scientists
  • Expand and integrate expertly curated information with your in-house data
  • Enhance artificial intelligence applications with high quality curated data
  • Improve the performance of predictive analytics
  • Build adverse event-based systems toxicology models
  • Build chemoinformatic models to predict adverse effects from chemical structures
  • Extend the value of your visualization capabilities to better support internal projects
15,334TARGETS & GENES
24,592DRUGS, BIOLOGICS & DRUG COMBINATIONS
1,331,832SAFETY ALERTS
10,804ADVERSE EVENTS
OFF-X API
EMPOWER YOUR INTERNAL SAFETY INTELLIGENCE
Connect to the most comprehensive translational safety data ecosystem through our APIs or data feed licenses. As of August 2021, OFF-X covers More than 15,334 targets, 24,592 drugs and biologics, 10,804 toxicity endpoints and adverse events. Updated daily, the portal is populated with a unique pool of more than 1,331,832 expertly curated safety alerts.

By integrating the OFF-X data with in-house information sources and modeling applications our customers are able to:
  • Enrich and expand the breadth & depth of internal resources coverage
  • Build Artificial Intelligence models with high quality curated data
  • Enhance the performance of predictive analytics
Click here to learn more about OFF-X API (api.targetsafety.info)
OFF-X
NEWS