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COVERAGE AS OF
OCTOBER 2021:
1,393,319SAFETY ALERTS
15,327TARGETS & GENES
25,223DRUGS, BIOLOGICS & DRUG COMBINATIONS
10,931ADVERSE EVENTS
COVERAGE AS OF OCTOBER 2021:
1,393,319
SAFETY ALERTS
15,327
TARGETS & GENES
25,223
DRUGS, BIOLOGICS & DRUG COMBINATIONS
10,931
ADVERSE EVENTS
WEEKLY REPORTS
COVID-19 DAILY ALERTS
SELECTED
DAILY ALERTS
FEATURED
CONGRESS REPORTS
Our editorial team covers more than 500 scientific conferences each year. Select a congress to discover safety insights made public for the first time:
  • SELECTED
    REPORTS
  • UPCOMING
    CONGRESSES
Oct 3-5
UEG Week Virtual 2021, Virtual
IN PROGRESS
Sep 23-26
16th International Symposium on Myelodysplastic Syndromes 2021, Virtual
IN PROGRESS
Sep 20-24
WMS Virtual Congress 2021, Virtual
IN PROGRESS
Sep 19-21
27th European Paediatric Rheumatology Congress (PReS) 2021, Virtual
IN PROGRESS
Sep 17-22
MDS Virtual Congress 2021, Virtual
IN PROGRESS
Sep 16-21
ESMO Congress 2021 , Virtual
Sep 13-17
24th North American Meeting of the International Society for the Study of Xenobiotics (ISSX) 2021, Virtual
Sep 13-17
Annual Meeting of the American College of Clinical Pharmacology (ACCP) 2021, Virtual
Sep 10-13
American Urological Association (AUA) Annual Meeting 2021, Virtual
Sep 10-13
HFSA Virtual Annual Scientific Meeting 2021, Denver
Sep 9-12
EURETINA 2021, Virtual
Sep 9-11
European Huntington's Disease Network (EHDN) Plenary Meeting 2021, Remote
Sep 8-11
18th International Myeloma Workshop (IMW) 2021, Vienna
Sep 8-11
Society of Hematologic Oncology (SOHO) Annual Meeting 2021, Virtual
Sep 8-12
The International Headache Congress, IHS and EHF Joint Congress 2021, Virtual
Sep 8-14
World Conference on Lung Cancer 2021, Virtual
Sep 7-11
PAINWeek Conference 2021, Las Vegas
Sep 5-8
European Respiratory Society International Congress (ERS) 2021, Virtual
Sep 2-5
15th ILCA Conference 2021, Virtual
Sep 1-3
European Stroke Organisation Conference ​(ESOC) 2021, Virtual
Aug 30-Sep 2
IGCS Annual Global Meeting 2021, Virtual
Aug 29-Sep 1
20th Congress of the European Society for Organ Transplantation (ESOT) 2021, Milan & Online
Aug 28-Sep 1
34th International Epilepsy Congress 2021, Virtual
Aug 28-31
European Human Genetics Conference (ESHG) 2021, Virtual
Aug 27-30
European Society of Cardiology (ESC) Congress 2021, Digital
Aug 26-28
NHF Bleeding Disorders Conference 2021, Virtual
Aug 26-28
World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (WCO IOF-ESCEO) 2021, Virtual
Aug 23-25
Basic Cardiovascular Sciences Scientific Sessions (BCVS) 2021, Virtual
Aug 12-15
Pan-American Congress of Rheumatology (PANLAR) 2021, Virtual
Aug 7-8
14th Australasian Cystic Fibrosis Conference 2021, Virtual
Aug 5-8
American Academy of Dermatology (AAD) Summer Meeting 2021, Tampa
OFF-X ANALYTICS
DATA IN ACTION TO DE-RISK YOUR R&D PROGRAMS
OFF-X is built from the most comprehensive translational safety dataset (1,393,319 curated alerts as of October 2021). We are providing access to a series of analytics and visualization extensions to fully exploit the value of the OFF-X dataset and derive new knowledge. Select your option below and start exploring
OFF-X
ENABLING TRANSLATIONAL SAFETY
By enabling translational research, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post marketing. From target safety assessment to post-marketing signal evaluation, discover the breadth and depth of OFF-X use cases:
Translational Research Teams & Information Professionals
Biologists & Bioinformaticians
Medicinal Chemists
Toxicologists & Safety Pharmacologists
Clinical
Researchers
Pharmacovigilance Professionals
Business Development Executives
Data Scientists
0
Biologists & Bioinformaticians
  • Anticipate safety liabilities of targets entering the pipeline: Target Safety Assessment (TSA)
  • Benchmark target safety profiles across a given indication
  • Build adverse event-based systems toxicology models
Medicinal Chemists
  • Analyze structures to select candidates and optimize lead compounds by identifying toxicophores
  • Compare chemical and pharmacological insights associated to toxicological and safety endpoints
  • Build computational models to predict adverse effects from chemical structures
Toxicologists & Safety Pharmacologists
  • Anticipate and translate to the clinic toxicity and safety events derived from experimental assays and animal models
  • Develop hypotheses for off-target effects (secondary pharmacology profiling) and guide experimental assay planning
  • Determine if an adverse event is compound-related or target-related
  • Stay up-to-date on liabilities associated with a therapeutic target of interest
Clinical Researchers
  • Obtain actionable insights to design first-in-human trials and anticipate safety signals
  • Benchmark the safety profile of compounds as they advance in development
  • Discover mechanisms behind unexpected adverse events observed in a clinical trial
Pharmacovigilance & Patient Safety Professionals
  • Evaluate safety signals that do not appear on a drug's label
  • Compare findings from international regulatory agencies
  • Track & benchmark the evolution of safety evidence over a compound’s or target’s life cycle and compare it with that of others drugs
  • Monitor emerging class liabilities
  • Assess and compare the safety evidence available for a set of targets in a given indication
Business Development Executives
  • Perform safety evidence benchmarking
  • Provide an independent safety risk assessment of licensing opportunities
Data Scientists
  • Expand and integrate expertly curated information with your in-house data
  • Enhance artificial intelligence applications with high quality curated data
  • Improve the performance of predictive analytics
  • Build adverse event-based systems toxicology models
  • Build chemoinformatic models to predict adverse effects from chemical structures
  • Extend the value of your visualization capabilities to better support internal projects
15,327TARGETS & GENES
25,223DRUGS, BIOLOGICS & DRUG COMBINATIONS
1,393,319SAFETY ALERTS
10,931ADVERSE EVENTS
OFF-X API
EMPOWER YOUR INTERNAL SAFETY INTELLIGENCE
Connect to the most comprehensive translational safety data ecosystem through our APIs or data feed licenses. As of October 2021, OFF-X covers More than 15,327 targets, 25,223 drugs and biologics, 10,931 toxicity endpoints and adverse events. Updated daily, the portal is populated with a unique pool of more than 1,393,319 expertly curated safety alerts.

By integrating the OFF-X data with in-house information sources and modeling applications our customers are able to:
  • Enrich and expand the breadth & depth of internal resources coverage
  • Build Artificial Intelligence models with high quality curated data
  • Enhance the performance of predictive analytics
Click here to learn more about OFF-X API (api.targetsafety.info)
OFF-X
NEWS